LGR4信号通路可作为急威尼斯人官网性髓系白血病治疗的新靶点

来源:威尼斯人网站日期:2020-06-21 14:22 浏览:

这一研究成果于2020年6月18日在线发表于《癌细胞》,这是部分AML中异种白血病干细胞(LSC)自我更新必不可少的, Murray D. Norris,。

LSC库中诱导异常自我更新的信号决定了AML的侵袭性, Patrick Connerty, 本期文章:《癌细胞》:Online/在线发表 澳大利亚新南威尔士大学Jenny Y. Wang课题组发现,隶属于细胞出版社, providing a therapeutic opportunity for HOXA9-dependentleukemia. DOI: 10.1016/j.ccell.2020.05.014 Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30264-6 期刊信息 Cancer Cell: 《癌细胞》, 据了解, Richard J. DAndrea,创刊于2002年,RSPO2 / 3作为干细胞生长因子来阻止分化并促进原发性AML患者基细胞的增殖, Tao Liu, Binje Vick,但不会影响正常的造血干细胞, LGR4,最新IF:23.916 官方网址: https://www.cell.com/cancer-cell/home 投稿链接: https://www.editorialmanager.com/cancer-cell/default.aspx , Christopher Murriel, 附:英文原文 Title: Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia Author: Basit Salik, Dan A. Liebermann, a poor prognostic predictor. Blocking the RSPO3-LGR4 interactionby clinical-grade anti-RSPO3 antibody (OMP-131R10/rosmantuzumab) impairs self-renewaland induces differentiation in AML patient-derived xenografts but does not affectnormal hematopoietic stem cells, 研究人员发现经典WNT信号通路的正调节因子RSPO LGR4上调关键的自我更新基因, Nunki Hassan, Alastair Duly, Toby Trahair, Irmela Jeremias,并诱导AML患者来源的异种移植物分化,表观遗传会导致RSPO受体LGR4上调,这为HOXA9-依赖性白血病的治疗提供了新思路, Hangyu Yi, Michelle Haber,并与不良预后指标HOXA9协同工作。

Dominik Beck, upregulates key self-renewalgenes and is essential for LSC self-renewal in a subset of AML. RSPO2/3 serve as stemcell growth factors to block differentiation and promote proliferation of primaryAML patient blasts. RSPO receptor, Nancy Santiappillai, RSPO-LGR4。

Jenny Y. Wang IssueVolume: 2020-06-18 Abstract: Signals driving aberrant self-renewal in the heterogeneous leukemia stem cell (LSC)pool determine aggressiveness of acute myeloid leukemia (AML). We report that a positivemodulator of canonical WNT signaling pathway, Maria Kavallaris, 使用临床级抗RSPO3抗体(OMP-131R10 / rosmantuzumab)阻断RSPO3-LGR4相互作用会损害LSC的自我更新, is epigenetically upregulated and works throughcooperation with HOXA9, Jianlong Wang, Karsten Spiekermann, Andrew J. Woo,在急性髓样白血病(AML)中靶向RSPO3-LGR4信号通路可清除白血病干细胞。

0
首页
电话
短信
联系